Evaluation of repeat cycles after fertilization failures in FIV/ICSI cycles. By Pedro Ferreira

Posted by on in 3. Medical and Health Sciences, 3.2 Clinical medicine, Communication, ISSUE 3, Português

Details

 Video type: Communication Knowledge Field: Clinical medicine Language: Portuguese Issue: ISSUE 3, December 2021

Evaluation of Repeat Cycles After Fertilization Failures in FIV/ICSI Cycles.

Avaliação de ciclos de repetição após falhas de fertilização em ciclos FIV/ICSI.

Ferreira, P.1; Ramos, S.1; Garcia, J.1; Metello, J.1 and Simões dos Reis, I.1

1) Hospital Garcia de Orta, Almada, Portugal

Filmed: 25/09/2021 Submitted: 16/12/2021 Published: 27/12/2021
CITE THIS VIDEO-ARTICLE

Ferreira, P. (2021). Evaluation of repeat cycles after fertilization failures in FIV/ICSI cycles. AcademyOn(3)Retrieved from https://www.academy-on.com/videos/pedro-ferreira-3/

SYNOPSIS

In this communication the author highlights the subsequent cycles after fertilization failures and presents the results and importance of those cycles.

Nesta comunicação o autor realça os ciclos subsequentes após falhas de fecundação e apresenta os resultados e importância daqueles ciclos.

AUTHOR BIOGRAPHY

Pedro Ferreira is a clinical embryologist at Hospital Garcia de Orta, Almada, Portugal. His research interests are embryology and andrology.

ABSTRACT

With the evolution of Assisted Reproduction Techniques, fertilization rates reach values of 70-80%. However, fertilization failure is still a reality with serious economic and emotional consequences, both for patients and professionals. Total fertilization failure (TFF), which corresponds to the absence of fertilization in all oocytes, occurs in 5-10% of conventional in vitro fertilization (IVF) cycles. In sperm microinjection cycles (ICSI-Intracytoplasmatic Sperm Injection), about 30% of human oocytes do not fertilize and TFF occurs in 2-3% of those cycles. Fertilization failure in IVF cycles is mainly due to sperm abnormalities, whereas in ICSI cycles, defects in oocyte activation are the predominant cause. The probability of repeating an TFF in the same couple in a subsequent cycle is approximately 30%, so the assessment of fertilization failures is important, in order to optimize the results of a future treatment and enable better patient counseling.

Com a evolução das Técnicas de Reprodução Assistida, as taxas de fertilização atingem valores de 70-80%. No entanto, a falha de fertilização é ainda uma realidade com consequências graves a nível económico e emocional, tanto para os pacientes como para os profissionais. A falha total de fertilização (FTF), que corresponde à ausência de fertilização em todos os ovócitos, ocorre em 5-10% dos ciclos de fertilização in vitro convencional (FIV). Nos ciclos de microinjecção de espermatozoides (ICSI-Intracitoplasmatic Sperm Injection), cerca de 30% dos ovócitos humanos não fertilizam e a FTF ocorre em 2-3% daqueles ciclos. A falha de fertilização nos ciclos FIV deve-se principalmente a anomalias do esperma, enquanto nos ciclos de ICSI, os defeitos na activação do ovócito são a causa predominante. A probabilidade de repetição de uma FTF no mesmo casal num ciclo subsequente é de aproximadamente 30%, pelo que a avaliação das falhas de fertilização é importante, de forma optimizar os resultados de um futuro tratamento e possibilitar um melhor aconselhamento dos pacientes.

 KEYWORDS

Fertilization failure, IVF, ICSI.
Falhas de fecundação, FIV, ICSI.

 DISCLOSURES

The author certifies that there is no actual or potential conflict of interest in relation to this video article.

REFERENCES

Swain JE, Pool TB. ART failure: oocyte contributions to unsuccessful fertilization. Hum Reprod Update. 2008;14:431–446. doi: 10.1093/humupd/dmn025

Mahutte NG, Arici A. Failed fertilization: is it predictable? Curr Opin Obstet Gynecol. 2003;15:211–218. doi: 10.1097/00001703-200306000-00001

Bhattacharya S, Hamilton MP, Shaaban M, Khalaf Y, Seddler M, Ghobara T, et al. Conventional in-vitro fertilisation versus intracytoplasmic sperm injection for the treatment of non-male-factor infertility: a randomised controlled trial. Lancet. 2001;357:2075–2079. doi: 10.1016/S0140-6736(00)05179-5

Combelles CM, Morozumi K, Yanagimachi R, Zhu L, Fox JH, Racowsky C. Diagnosing cellular defects in an unexplained case of total fertilization failure. Hum Reprod. 2010;25:1666–1671. doi: 10.1093/humrep/deq064

Barlow P, Englert Y, Puissant F, Lejeune B, Delvigne A, Van Rysselberge M, et al. Fertilization failure in IVF: why and what next? Hum Reprod. 1990;5:451–456.

Kahyaoglu I, Demir B, Turkkani A, Cinar O, Dilbaz S, Dilbaz B, Mollamahmutoglu L. Total fertilization failure: is it the end of the story?. J Assist Reprod Genet 2014;31:1155-1160.

SCIENTIFIC EVENT

XXXVII Reproductive Studies Journeys, September 24-25, 2021, Lisbon, Portugal.
Organized by: Portuguese Society for Reproductive Medicine


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